Protein Details: Aquaporin Z
Protein ID
ICDB_Pro_1154
Protein Name
Aquaporin Z
Gene Name
aqpZ; CV_2864
Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Length
229 amino acids
AlphaFoldDB
AF-Q7NU39-F1-model_v4.pdb
Function
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
Sequence
MKSYGAEFLGTFWLVLGGCGSAVLAAGFPNLGIGFAGVALAFGLTVVTMAYAIGHISGCHLNPAVSIGLWAGGRFPAGQLAPYIVAQVLGAIAAGAVLYVIASGGAGFDVAKGFASNGYAEHSPGGYSLLAALVCEVVMTMFFLLVIMGATDKRAPAGFAPLAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWAVQQLWLFWLAPIIGAVLGAKVYRLIAGESE
PDB Structures
Ligand Binding
Binding Site
SITE 19: "Involved in tetramerization or stability of the tetramer"; SITE 42: "Selectivity filter"; SITE 172: "Selectivity filter"; SITE 181: "Selectivity filter"; SITE 187: "Selectivity filter"
Disease
Location
DOI ID
10.1073/pnas.1832124100
RefSeq
WP_011136411.1